Rapamycin A Drug Commonly Used In The Treatment Of Cancer Is Emerging As A Powerful Antiaging Drug

Rapamycin is a cell growth inhibitor and immunosuppressant that people commonly receive while undergoing cancer treatment or after receiving an organ transplant. A team from the Max Planck Institute for the Biology of Aging, however, notes that the drug is also a promising anti-aging formula. Animal studies have found that low doses of rapamycin can extend life by preventing age-related changes in the intestines. Until now, however, scientists viewed this drug as something patients would have to take for the rest of their lives. READ: Taurine supplements could be the key to reversing the aging process “At doses used clinically, rapamycin can have unwanted side effects, but for the drug’s use in preventing age-related decline, these should be absent or minimal. So we wanted to know when and how long we should give rapamycin to achieve the same results as lifelong treatment,” explains lead researcher Dr. Paula Juricic in a university statement.

Is rapamycin treatment more effective when taken earlier in life?

The new study tested rapamycin in two short-term experiments using fruit flies and laboratory mice. The first young, treated adults fly for two weeks. The second treated young, adult mice (3 months old) for a period of three months. In both experiments, the team found that rapamycin had a beneficial effect on the gut health of each animal during middle age. “These brief drug treatments in early adulthood produced as strong protection as continuous treatment started at the same time. We also found that rapamycin treatment had the strongest and best results when given in early life compared to midlife. When the flies were treated with rapamycin late in life, on the other hand, it had absolutely no effect. Thus, rapamycin memory is mainly activated in early adulthood,” explains Dr. Thomas Leech, co-author of the paper. “We found a way to bypass the need for chronic, long-term rapamycin, so it could be more practical to apply in humans,” adds co-author Dr. Yu-Xuan Lu. READ: ‘Fountain of youth’ pill shows ability to dramatically increase longevity in mice “It will be important to find out if it is possible to achieve the geroprotective effects of rapamycin in mice and humans with treatment starting later in life, as ideally the treatment period should be minimized. It may also be possible to use intermittent dosing. This study opened new doors, but also many new questions,” concludes senior author Professor Linda Partridge. More research is needed to confirm the study’s results while proving that rapamycin can be safely used as an anti-aging drug. The study is published in the journal Nature Aging.

title: “Rapamycin A Drug Commonly Used In The Treatment Of Cancer Is Emerging As A Powerful Antiaging Drug Klmat” ShowToc: true date: “2022-12-09” author: “Dustin Hudson”

Rapamycin is a cell growth inhibitor and immunosuppressant that people commonly receive while undergoing cancer treatment or after receiving an organ transplant. A team from the Max Planck Institute for the Biology of Aging, however, notes that the drug is also a promising anti-aging formula. Animal studies have found that low doses of rapamycin can extend life by preventing age-related changes in the intestines. Until now, however, scientists viewed this drug as something patients would have to take for the rest of their lives. READ: Taurine supplements could be the key to reversing the aging process “At doses used clinically, rapamycin can have unwanted side effects, but for the drug’s use in preventing age-related decline, these should be absent or minimal. So we wanted to know when and how long we should give rapamycin to achieve the same results as lifelong treatment,” explains lead researcher Dr. Paula Juricic in a university statement.

Is rapamycin treatment more effective when taken earlier in life?

The new study tested rapamycin in two short-term experiments using fruit flies and laboratory mice. The first young, treated adults fly for two weeks. The second treated young, adult mice (3 months old) for a period of three months. In both experiments, the team found that rapamycin had a beneficial effect on the gut health of each animal during middle age. “These brief drug treatments in early adulthood produced as strong protection as continuous treatment started at the same time. We also found that rapamycin treatment had the strongest and best results when given in early life compared to midlife. When the flies were treated with rapamycin late in life, on the other hand, it had absolutely no effect. Thus, rapamycin memory is mainly activated in early adulthood,” explains Dr. Thomas Leech, co-author of the paper. “We found a way to bypass the need for chronic, long-term rapamycin, so it could be more practical to apply in humans,” adds co-author Dr. Yu-Xuan Lu. READ: ‘Fountain of youth’ pill shows ability to dramatically increase longevity in mice “It will be important to find out if it is possible to achieve the geroprotective effects of rapamycin in mice and humans with treatment starting later in life, as ideally the treatment period should be minimized. It may also be possible to use intermittent dosing. This study opened new doors, but also many new questions,” concludes senior author Professor Linda Partridge. More research is needed to confirm the study’s results while proving that rapamycin can be safely used as an anti-aging drug. The study is published in the journal Nature Aging.

title: “Rapamycin A Drug Commonly Used In The Treatment Of Cancer Is Emerging As A Powerful Antiaging Drug Klmat” ShowToc: true date: “2022-11-19” author: “Debra Merkle”

Rapamycin is a cell growth inhibitor and immunosuppressant that people commonly receive while undergoing cancer treatment or after receiving an organ transplant. A team from the Max Planck Institute for the Biology of Aging, however, notes that the drug is also a promising anti-aging formula. Animal studies have found that low doses of rapamycin can extend life by preventing age-related changes in the intestines. Until now, however, scientists viewed this drug as something patients would have to take for the rest of their lives. READ: Taurine supplements could be the key to reversing the aging process “At doses used clinically, rapamycin can have unwanted side effects, but for the drug’s use in preventing age-related decline, these should be absent or minimal. So we wanted to know when and how long we should give rapamycin to achieve the same results as lifelong treatment,” explains lead researcher Dr. Paula Juricic in a university statement.

Is rapamycin treatment more effective when taken earlier in life?

The new study tested rapamycin in two short-term experiments using fruit flies and laboratory mice. The first young, treated adults fly for two weeks. The second treated young, adult mice (3 months old) for a period of three months. In both experiments, the team found that rapamycin had a beneficial effect on the gut health of each animal during middle age. “These brief drug treatments in early adulthood produced as strong protection as continuous treatment started at the same time. We also found that rapamycin treatment had the strongest and best results when given in early life compared to midlife. When the flies were treated with rapamycin late in life, on the other hand, it had absolutely no effect. Thus, rapamycin memory is mainly activated in early adulthood,” explains Dr. Thomas Leech, co-author of the paper. “We found a way to bypass the need for chronic, long-term rapamycin, so it could be more practical to apply in humans,” adds co-author Dr. Yu-Xuan Lu. READ: ‘Fountain of youth’ pill shows ability to dramatically increase longevity in mice “It will be important to find out if it is possible to achieve the geroprotective effects of rapamycin in mice and humans with treatment starting later in life, as ideally the treatment period should be minimized. It may also be possible to use intermittent dosing. This study opened new doors, but also many new questions,” concludes senior author Professor Linda Partridge. More research is needed to confirm the study’s results while proving that rapamycin can be safely used as an anti-aging drug. The study is published in the journal Nature Aging.

title: “Rapamycin A Drug Commonly Used In The Treatment Of Cancer Is Emerging As A Powerful Antiaging Drug Klmat” ShowToc: true date: “2022-11-17” author: “Timothy Manns”

Rapamycin is a cell growth inhibitor and immunosuppressant that people commonly receive while undergoing cancer treatment or after receiving an organ transplant. A team from the Max Planck Institute for the Biology of Aging, however, notes that the drug is also a promising anti-aging formula. Animal studies have found that low doses of rapamycin can extend life by preventing age-related changes in the intestines. Until now, however, scientists viewed this drug as something patients would have to take for the rest of their lives. READ: Taurine supplements could be the key to reversing the aging process “At doses used clinically, rapamycin can have unwanted side effects, but for the drug’s use in preventing age-related decline, these should be absent or minimal. So we wanted to know when and how long we should give rapamycin to achieve the same results as lifelong treatment,” explains lead researcher Dr. Paula Juricic in a university statement.

Is rapamycin treatment more effective when taken earlier in life?

The new study tested rapamycin in two short-term experiments using fruit flies and laboratory mice. The first young, treated adults fly for two weeks. The second treated young, adult mice (3 months old) for a period of three months. In both experiments, the team found that rapamycin had a beneficial effect on the gut health of each animal during middle age. “These brief drug treatments in early adulthood produced as strong protection as continuous treatment started at the same time. We also found that rapamycin treatment had the strongest and best results when given in early life compared to midlife. When the flies were treated with rapamycin late in life, on the other hand, it had absolutely no effect. Thus, rapamycin memory is mainly activated in early adulthood,” explains Dr. Thomas Leech, co-author of the paper. “We found a way to bypass the need for chronic, long-term rapamycin, so it could be more practical to apply in humans,” adds co-author Dr. Yu-Xuan Lu. READ: ‘Fountain of youth’ pill shows ability to dramatically increase longevity in mice “It will be important to find out if it is possible to achieve the geroprotective effects of rapamycin in mice and humans with treatment starting later in life, as ideally the treatment period should be minimized. It may also be possible to use intermittent dosing. This study opened new doors, but also many new questions,” concludes senior author Professor Linda Partridge. More research is needed to confirm the study’s results while proving that rapamycin can be safely used as an anti-aging drug. The study is published in the journal Nature Aging.