A fecal microbe transplant (FMT) involves getting healthy bacteria “in a mixture of prepared treated stool from a healthy donor” into another person’s gut. The National Institute for Health and Care Excellence (Nice) says the procedure should be considered for patients who have had two or more treatments for Clostridium difficile (C.diff) without success. Treating these people with gut bacteria taken from the feces of a healthy person can help restore healthy gut bacteria, Nice said. C.diff is a type of bacteria that can cause diarrhea and often affects people taking antibiotics. The germ can usually be treated with a different type of antibiotic, but is sometimes referred to as a “superbug” because of its resistance to treatment in some cases. Nice said clinical trials have shown that FMT treatment is significantly better than antibiotics alone in resolving a persistent C.diff infection and treatment with this method could save the NHS thousands of pounds. Patients may need to take fewer antibiotics and have reported better quality of life after treatment, he added. ‘Innovator’ The FMT portion can be swallowed in a pill, or it can be administered through a tube inserted directly into the stomach through the nose, or alternatively deposited directly into the colon, also through a tube. Mark Chapman, interim director of medical technology at Nice, said: “There is a need today for effective treatment of C.diff in people who have received two or more rounds of antibiotics. “Our panel’s recommendation for this innovative treatment will provide another tool for healthcare professionals to fight this infection while balancing the need to deliver the best value for money care. “Using this treatment will also help reduce antibiotic dependency and in turn reduce the chances of antimicrobial resistance, which supports NICE guidance on good antimicrobial stewardship.” Study Nice said it made its decision to go ahead with FMT after reviewing data from five trials in 274 adults, which showed that more C.diff infections resolved with FMT than antibiotic therapy in four of the trials – and there was no difference to the others. The data also showed that the treatment can resolve up to 94% of infections. FMT can be much cheaper than antibiotics if given as an oral capsule – saving more than £8,000. it can save hundreds of pounds if given as a colonoscopy, but is more expensive when given as an enema. Nice has estimated that 450 to 500 people in England could be treated using FMT for multiple recurrences of C.diff infections each year. He said there should be a strict program of donor screening and that treatments should be prepared according to human medicine regulations. All donors will be screened beforehand to ensure that the faeces provided are healthy and tested for a wide range of viral, bacterial and parasitic infections, which also includes testing for COVID-19.

title: “Fecal Transplants To Be Offered To Hundreds With Antibiotic Resistant Superbiotic Uk News Klmat” ShowToc: true date: “2022-11-24” author: “Margaret Rapp”

A fecal microbe transplant (FMT) involves getting healthy bacteria “in a mixture of prepared treated stool from a healthy donor” into another person’s gut. The National Institute for Health and Care Excellence (Nice) says the procedure should be considered for patients who have had two or more treatments for Clostridium difficile (C.diff) without success. Treating these people with gut bacteria taken from the feces of a healthy person can help restore healthy gut bacteria, Nice said. C.diff is a type of bacteria that can cause diarrhea and often affects people taking antibiotics. The germ can usually be treated with a different type of antibiotic, but is sometimes referred to as a “superbug” because of its resistance to treatment in some cases. Nice said clinical trials have shown that FMT treatment is significantly better than antibiotics alone in resolving a persistent C.diff infection and treatment with this method could save the NHS thousands of pounds. Patients may need to take fewer antibiotics and have reported better quality of life after treatment, he added. ‘Innovator’ The FMT portion can be swallowed in a pill, or it can be administered through a tube inserted directly into the stomach through the nose, or alternatively deposited directly into the colon, also through a tube. Mark Chapman, interim director of medical technology at Nice, said: “There is a need today for effective treatment of C.diff in people who have received two or more rounds of antibiotics. “Our panel’s recommendation for this innovative treatment will provide another tool for healthcare professionals to fight this infection while balancing the need to deliver the best value for money care. “Using this treatment will also help reduce antibiotic dependency and in turn reduce the chances of antimicrobial resistance, which supports NICE guidance on good antimicrobial stewardship.” Study Nice said it made its decision to go ahead with FMT after reviewing data from five trials in 274 adults, which showed that more C.diff infections resolved with FMT than antibiotic therapy in four of the trials – and there was no difference to the others. The data also showed that the treatment can resolve up to 94% of infections. FMT can be much cheaper than antibiotics if given as an oral capsule – saving more than £8,000. it can save hundreds of pounds if given as a colonoscopy, but is more expensive when given as an enema. Nice has estimated that 450 to 500 people in England could be treated using FMT for multiple recurrences of C.diff infections each year. He said there should be a strict program of donor screening and that treatments should be prepared according to human medicine regulations. All donors will be screened beforehand to ensure that the faeces provided are healthy and tested for a wide range of viral, bacterial and parasitic infections, which also includes testing for COVID-19.

title: “Fecal Transplants To Be Offered To Hundreds With Antibiotic Resistant Superbiotic Uk News Klmat” ShowToc: true date: “2022-10-21” author: “Rosa Sallee”

A fecal microbe transplant (FMT) involves getting healthy bacteria “in a mixture of prepared treated stool from a healthy donor” into another person’s gut. The National Institute for Health and Care Excellence (Nice) says the procedure should be considered for patients who have had two or more treatments for Clostridium difficile (C.diff) without success. Treating these people with gut bacteria taken from the feces of a healthy person can help restore healthy gut bacteria, Nice said. C.diff is a type of bacteria that can cause diarrhea and often affects people taking antibiotics. The germ can usually be treated with a different type of antibiotic, but is sometimes referred to as a “superbug” because of its resistance to treatment in some cases. Nice said clinical trials have shown that FMT treatment is significantly better than antibiotics alone in resolving a persistent C.diff infection and treatment with this method could save the NHS thousands of pounds. Patients may need to take fewer antibiotics and have reported better quality of life after treatment, he added. ‘Innovator’ The FMT portion can be swallowed in a pill, or it can be administered through a tube inserted directly into the stomach through the nose, or alternatively deposited directly into the colon, also through a tube. Mark Chapman, interim director of medical technology at Nice, said: “There is a need today for effective treatment of C.diff in people who have received two or more rounds of antibiotics. “Our panel’s recommendation for this innovative treatment will provide another tool for healthcare professionals to fight this infection while balancing the need to deliver the best value for money care. “Using this treatment will also help reduce antibiotic dependency and in turn reduce the chances of antimicrobial resistance, which supports NICE guidance on good antimicrobial stewardship.” Study Nice said it made its decision to go ahead with FMT after reviewing data from five trials in 274 adults, which showed that more C.diff infections resolved with FMT than antibiotic therapy in four of the trials – and there was no difference to the others. The data also showed that the treatment can resolve up to 94% of infections. FMT can be much cheaper than antibiotics if given as an oral capsule – saving more than £8,000. it can save hundreds of pounds if given as a colonoscopy, but is more expensive when given as an enema. Nice has estimated that 450 to 500 people in England could be treated using FMT for multiple recurrences of C.diff infections each year. He said there should be a strict program of donor screening and that treatments should be prepared according to human medicine regulations. All donors will be screened beforehand to ensure that the faeces provided are healthy and tested for a wide range of viral, bacterial and parasitic infections, which also includes testing for COVID-19.

title: “Fecal Transplants To Be Offered To Hundreds With Antibiotic Resistant Superbiotic Uk News Klmat” ShowToc: true date: “2022-10-25” author: “Claudia Castro”

A fecal microbe transplant (FMT) involves getting healthy bacteria “in a mixture of prepared treated stool from a healthy donor” into another person’s gut. The National Institute for Health and Care Excellence (Nice) says the procedure should be considered for patients who have had two or more treatments for Clostridium difficile (C.diff) without success. Treating these people with gut bacteria taken from the feces of a healthy person can help restore healthy gut bacteria, Nice said. C.diff is a type of bacteria that can cause diarrhea and often affects people taking antibiotics. The germ can usually be treated with a different type of antibiotic, but is sometimes referred to as a “superbug” because of its resistance to treatment in some cases. Nice said clinical trials have shown that FMT treatment is significantly better than antibiotics alone in resolving a persistent C.diff infection and treatment with this method could save the NHS thousands of pounds. Patients may need to take fewer antibiotics and have reported better quality of life after treatment, he added. ‘Innovator’ The FMT portion can be swallowed in a pill, or it can be administered through a tube inserted directly into the stomach through the nose, or alternatively deposited directly into the colon, also through a tube. Mark Chapman, interim director of medical technology at Nice, said: “There is a need today for effective treatment of C.diff in people who have received two or more rounds of antibiotics. “Our panel’s recommendation for this innovative treatment will provide another tool for healthcare professionals to fight this infection while balancing the need to deliver the best value for money care. “Using this treatment will also help reduce antibiotic dependency and in turn reduce the chances of antimicrobial resistance, which supports NICE guidance on good antimicrobial stewardship.” Study Nice said it made its decision to go ahead with FMT after reviewing data from five trials in 274 adults, which showed that more C.diff infections resolved with FMT than antibiotic therapy in four of the trials – and there was no difference to the others. The data also showed that the treatment can resolve up to 94% of infections. FMT can be much cheaper than antibiotics if given as an oral capsule – saving more than £8,000. it can save hundreds of pounds if given as a colonoscopy, but is more expensive when given as an enema. Nice has estimated that 450 to 500 people in England could be treated using FMT for multiple recurrences of C.diff infections each year. He said there should be a strict program of donor screening and that treatments should be prepared according to human medicine regulations. All donors will be screened beforehand to ensure that the faeces provided are healthy and tested for a wide range of viral, bacterial and parasitic infections, which also includes testing for COVID-19.