The National Institute for Health and Care Excellence (Nice), the health regulator, has given the go-ahead for a faecal microbe transplant (FMT) to be offered to people who have been treated for two or more Clostridium difficile (C diff) infections without success. The revolutionary treatment aims to restore a healthy population of gut bacteria in sick patients by transferring a batch of different gut bacteria and other microorganisms from a healthy donor into the recipient’s gut. C diff is a type of bacteria that can cause diarrhea and often affects people taking antibiotics. People are more likely to get a C diff infection if they are over 65, have been in hospital or a care home for a long time, or if they have a weakened immune system – for example, from a long-term condition such as diabetes or kidney failure or treatments including chemotherapy. It can usually be treated with a different type of antibiotic, but it is referred to as an antimicrobial due to its resistance to treatment in some cases. Nice said clinical trials have shown that FMT treatments are significantly better than antibiotics alone in resolving a persistent C diff infection. The health regulator said it had been shown the treatment could save the NHS thousands of pounds. It could also mean patients could take fewer antibiotics and have a better quality of life after treatment, he added. The new bacteria can be delivered through a tube inserted directly into the stomach through the nose, or alternatively deposited directly into the colon through a tube or swallowed through a pill. Mark Chapman, interim director of medical technology at Nice, said: “There is currently a need for effective treatment of C diff in people who have received two or more rounds of antibiotics. “Our committee’s recommendation for this innovative treatment will provide another tool for healthcare professionals to use in the fight against this infection, while balancing the need to deliver the best value for money care. “Using this treatment will also help reduce antibiotic dependency and in turn reduce the chances of antimicrobial resistance, which supports the Nice guidelines on good antimicrobial stewardship.” Nice said it made its decision after looking at evidence from five trials in 274 adults. Archie Bland and Nimo Omer take you to the top stories and what they mean, free every weekday morning Privacy Notice: Newsletters may contain information about charities, online advertising and content sponsored by external parties. For more information, see our Privacy Policy. We use Google reCaptcha to protect our website and Google’s Privacy Policy and Terms of Service apply. The data showed that more C diff infections resolved with FMT than antibiotic therapy in four of the trials and there was no difference in the other. FMT can lead to different levels of clinical cure depending on how the treatment is administered, but could resolve up to 94 percent of infections, Nice said. Modeling shows that wound transplants are cheaper than treatment with almost all antibiotics. They save the NHS around £769 if given by colonoscopy and up to £8,297 if given by oral capsule. It costs £1,287 per patient more if given as an enema. But enema FMT would be an option only for the minority who can’t have FMT by another route, Nice said. Nice estimates that 450 to 500 people in England could be treated using FMT for multiple recurrences of C diff infections each year. He said there should be a strict program of donor screening and that treatments should be prepared according to human medicine regulations.
title: “Nhs Patients Battling Superbugs To Be Offered Poo Transplants Health Klmat” ShowToc: true date: “2022-12-08” author: “Nathaniel Hansen”
The National Institute for Health and Care Excellence (Nice), the health regulator, has given the go-ahead for a faecal microbe transplant (FMT) to be offered to people who have been treated for two or more Clostridium difficile (C diff) infections without success. The revolutionary treatment aims to restore a healthy population of gut bacteria in sick patients by transferring a batch of different gut bacteria and other microorganisms from a healthy donor into the recipient’s gut. C diff is a type of bacteria that can cause diarrhea and often affects people taking antibiotics. People are more likely to get a C diff infection if they are over 65, have been in hospital or a care home for a long time, or if they have a weakened immune system – for example, from a long-term condition such as diabetes or kidney failure or treatments including chemotherapy. It can usually be treated with a different type of antibiotic, but it is referred to as an antimicrobial due to its resistance to treatment in some cases. Nice said clinical trials have shown that FMT treatments are significantly better than antibiotics alone in resolving a persistent C diff infection. The health regulator said it had been shown the treatment could save the NHS thousands of pounds. It could also mean patients could take fewer antibiotics and have a better quality of life after treatment, he added. The new bacteria can be delivered through a tube inserted directly into the stomach through the nose, or alternatively deposited directly into the colon through a tube or swallowed through a pill. Mark Chapman, interim director of medical technology at Nice, said: “There is currently a need for effective treatment of C diff in people who have received two or more rounds of antibiotics. “Our committee’s recommendation for this innovative treatment will provide another tool for healthcare professionals to use in the fight against this infection, while balancing the need to deliver the best value for money care. “Using this treatment will also help reduce antibiotic dependency and in turn reduce the chances of antimicrobial resistance, which supports the Nice guidelines on good antimicrobial stewardship.” Nice said it made its decision after looking at evidence from five trials in 274 adults. Archie Bland and Nimo Omer take you to the top stories and what they mean, free every weekday morning Privacy Notice: Newsletters may contain information about charities, online advertising and content sponsored by external parties. For more information, see our Privacy Policy. We use Google reCaptcha to protect our website and Google’s Privacy Policy and Terms of Service apply. The data showed that more C diff infections resolved with FMT than antibiotic therapy in four of the trials and there was no difference in the other. FMT can lead to different levels of clinical cure depending on how the treatment is administered, but could resolve up to 94 percent of infections, Nice said. Modeling shows that wound transplants are cheaper than treatment with almost all antibiotics. They save the NHS around £769 if given by colonoscopy and up to £8,297 if given by oral capsule. It costs £1,287 per patient more if given as an enema. But enema FMT would be an option only for the minority who can’t have FMT by another route, Nice said. Nice estimates that 450 to 500 people in England could be treated using FMT for multiple recurrences of C diff infections each year. He said there should be a strict program of donor screening and that treatments should be prepared according to human medicine regulations.
title: “Nhs Patients Battling Superbugs To Be Offered Poo Transplants Health Klmat” ShowToc: true date: “2022-10-25” author: “Beulah Corona”
The National Institute for Health and Care Excellence (Nice), the health regulator, has given the go-ahead for a faecal microbe transplant (FMT) to be offered to people who have been treated for two or more Clostridium difficile (C diff) infections without success. The revolutionary treatment aims to restore a healthy population of gut bacteria in sick patients by transferring a batch of different gut bacteria and other microorganisms from a healthy donor into the recipient’s gut. C diff is a type of bacteria that can cause diarrhea and often affects people taking antibiotics. People are more likely to get a C diff infection if they are over 65, have been in hospital or a care home for a long time, or if they have a weakened immune system – for example, from a long-term condition such as diabetes or kidney failure or treatments including chemotherapy. It can usually be treated with a different type of antibiotic, but it is referred to as an antimicrobial due to its resistance to treatment in some cases. Nice said clinical trials have shown that FMT treatments are significantly better than antibiotics alone in resolving a persistent C diff infection. The health regulator said it had been shown the treatment could save the NHS thousands of pounds. It could also mean patients could take fewer antibiotics and have a better quality of life after treatment, he added. The new bacteria can be delivered through a tube inserted directly into the stomach through the nose, or alternatively deposited directly into the colon through a tube or swallowed through a pill. Mark Chapman, interim director of medical technology at Nice, said: “There is currently a need for effective treatment of C diff in people who have received two or more rounds of antibiotics. “Our committee’s recommendation for this innovative treatment will provide another tool for healthcare professionals to use in the fight against this infection, while balancing the need to deliver the best value for money care. “Using this treatment will also help reduce antibiotic dependency and in turn reduce the chances of antimicrobial resistance, which supports the Nice guidelines on good antimicrobial stewardship.” Nice said it made its decision after looking at evidence from five trials in 274 adults. Archie Bland and Nimo Omer take you to the top stories and what they mean, free every weekday morning Privacy Notice: Newsletters may contain information about charities, online advertising and content sponsored by external parties. For more information, see our Privacy Policy. We use Google reCaptcha to protect our website and Google’s Privacy Policy and Terms of Service apply. The data showed that more C diff infections resolved with FMT than antibiotic therapy in four of the trials and there was no difference in the other. FMT can lead to different levels of clinical cure depending on how the treatment is administered, but could resolve up to 94 percent of infections, Nice said. Modeling shows that wound transplants are cheaper than treatment with almost all antibiotics. They save the NHS around £769 if given by colonoscopy and up to £8,297 if given by oral capsule. It costs £1,287 per patient more if given as an enema. But enema FMT would be an option only for the minority who can’t have FMT by another route, Nice said. Nice estimates that 450 to 500 people in England could be treated using FMT for multiple recurrences of C diff infections each year. He said there should be a strict program of donor screening and that treatments should be prepared according to human medicine regulations.
title: “Nhs Patients Battling Superbugs To Be Offered Poo Transplants Health Klmat” ShowToc: true date: “2022-12-13” author: “Vernon Warren”
The National Institute for Health and Care Excellence (Nice), the health regulator, has given the go-ahead for a faecal microbe transplant (FMT) to be offered to people who have been treated for two or more Clostridium difficile (C diff) infections without success. The revolutionary treatment aims to restore a healthy population of gut bacteria in sick patients by transferring a batch of different gut bacteria and other microorganisms from a healthy donor into the recipient’s gut. C diff is a type of bacteria that can cause diarrhea and often affects people taking antibiotics. People are more likely to get a C diff infection if they are over 65, have been in hospital or a care home for a long time, or if they have a weakened immune system – for example, from a long-term condition such as diabetes or kidney failure or treatments including chemotherapy. It can usually be treated with a different type of antibiotic, but it is referred to as an antimicrobial due to its resistance to treatment in some cases. Nice said clinical trials have shown that FMT treatments are significantly better than antibiotics alone in resolving a persistent C diff infection. The health regulator said it had been shown the treatment could save the NHS thousands of pounds. It could also mean patients could take fewer antibiotics and have a better quality of life after treatment, he added. The new bacteria can be delivered through a tube inserted directly into the stomach through the nose, or alternatively deposited directly into the colon through a tube or swallowed through a pill. Mark Chapman, interim director of medical technology at Nice, said: “There is currently a need for effective treatment of C diff in people who have received two or more rounds of antibiotics. “Our committee’s recommendation for this innovative treatment will provide another tool for healthcare professionals to use in the fight against this infection, while balancing the need to deliver the best value for money care. “Using this treatment will also help reduce antibiotic dependency and in turn reduce the chances of antimicrobial resistance, which supports the Nice guidelines on good antimicrobial stewardship.” Nice said it made its decision after looking at evidence from five trials in 274 adults. Archie Bland and Nimo Omer take you to the top stories and what they mean, free every weekday morning Privacy Notice: Newsletters may contain information about charities, online advertising and content sponsored by external parties. For more information, see our Privacy Policy. We use Google reCaptcha to protect our website and Google’s Privacy Policy and Terms of Service apply. The data showed that more C diff infections resolved with FMT than antibiotic therapy in four of the trials and there was no difference in the other. FMT can lead to different levels of clinical cure depending on how the treatment is administered, but could resolve up to 94 percent of infections, Nice said. Modeling shows that wound transplants are cheaper than treatment with almost all antibiotics. They save the NHS around £769 if given by colonoscopy and up to £8,297 if given by oral capsule. It costs £1,287 per patient more if given as an enema. But enema FMT would be an option only for the minority who can’t have FMT by another route, Nice said. Nice estimates that 450 to 500 people in England could be treated using FMT for multiple recurrences of C diff infections each year. He said there should be a strict program of donor screening and that treatments should be prepared according to human medicine regulations.
